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Epiblast ground state is controlled by canonical Wnt/beta-catenin signaling in the postimplantation mouse embryo and epiblast stem cells.

T. Sumi, S. Oki, K. Kitajima and C. Meno

PLoS One (2013) 8:5 e63378. 

Wnt signaling regulates left-right axis formation in the node of mouse embryos.

K. Kitajima, S. Oki, Y. Ohkawa, T. Sumi and C. Meno

Dev Biol (2013) 380:2 222-32. 

The dynamic right-to-left translocation of Cerl2 is involved in the regulation and termination of Nodal activity in the mouse node.

J. M. Inacio, S. Marques, T. Nakamura, K. Shinohara, C. Meno, H. Hamada and J. A. Belo

PLoS One (2013) 8:3 e60406. 

Restriction of Wnt signaling in the dorsal otocyst determines semicircular canal formation in the mouse embryo.

T. Noda, S. Oki, K. Kitajima, T. Harada, S. Komune and C. Meno

Dev Biol (2012) 362:1 83-93. 

DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.

F. Sanematsu, M. Hirashima, M. Laurin, R. Takii, A. Nishikimi, K. Kitajima, G. Ding, M. Noda, Y. Murata, Y. Tanaka, S. Masuko, T. Suda, C. Meno, J. F. Cote, T. Nagasawa and Y. Fukui

Circ Res (2010) 107:9 1102-5. 

Dissecting the role of Fgf signaling during gastrulation and left-right axis formation in mouse embryos using chemical inhibitors.

S. Oki, K. Kitajima and C. Meno

Dev Dyn (2010) 239:6 1768-78. 

Planar polarization of node cells determines the rotational axis of node cilia.

M. Hashimoto, K. Shinohara, J. Wang, S. Ikeuchi, S. Yoshiba, C. Meno, S. Nonaka, S. Takada, K. Hatta, A. Wynshaw-Boris and H. Hamada

Nat Cell Biol (2010) 12:2 170-6. 

Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo.

M. Yamamoto, H. Beppu, K. Takaoka, C. Meno, E. Li, K. Miyazono and H. Hamada

J Cell Biol (2009) 184:2 323-34. 

Reversal of left-right asymmetry induced by aberrant Nodal signaling in the node of mouse embryos.

S. Oki, K. Kitajima, S. Marques, J. A. Belo, T. Yokoyama, H. Hamada and C. Meno

Development (2009) 136:23 3917-25. 

The mouse embryo autonomously acquires anterior-posterior polarity at implantation.

K. Takaoka, M. Yamamoto, H. Shiratori, C. Meno, J. Rossant, Y. Saijoh and H. Hamada

Dev Cell (2006) 10:4 451-9. 

Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system.

T. Nakamura, N. Mine, E. Nakaguchi, A. Mochizuki, M. Yamamoto, K. Yashiro, C. Meno and H. Hamada

Dev Cell (2006) 11:4 495-504. 

Basement membrane fragility underlies embryonic lethality in fukutin-null mice.

H. Kurahashi, M. Taniguchi, C. Meno, Y. Taniguchi, S. Takeda, M. Horie, H. Otani and T. Toda

Neurobiol Dis (2005) 19:1-2 208-17. 

Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo.

M. Yamamoto, Y. Saijoh, A. Perea-Gomez, W. Shawlot, R. R. Behringer, S. L. Ang, H. Hamada and C. Meno

Nature (2004) 428:6981 387-92. 

Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate.

M. Yamamoto, N. Mine, K. Mochida, Y. Sakai, Y. Saijoh, C. Meno and H. Hamada

Development (2003) 130:9 1795-804. 

Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion.

R. Sakuma, Y. Ohnishi Yi, C. Meno, H. Fujii, H. Juan, J. Takeuchi, T. Ogura, E. Li, K. Miyazono and H. Hamada

Genes Cells (2002) 7:4 401-12. 

Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks.

A. Perea-Gomez, F. D. Vella, W. Shawlot, M. Oulad-Abdelghani, C. Chazaud, C. Meno, V. Pfister, L. Chen, E. Robertson, H. Hamada, R. R. Behringer and S. L. Ang

Dev Cell (2002) 3:5 745-56. 

Establishment of vertebrate left-right asymmetry.

H. Hamada, C. Meno, D. Watanabe and Y. Saijoh

Nat Rev Genet (2002) 3:2 103-13. 

The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse.

M. Yamamoto, C. Meno, Y. Sakai, H. Shiratori, K. Mochida, Y. Ikawa, Y. Saijoh and H. Hamada

Genes Dev (2001) 15:10 1242-56. 

The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo.

Y. Sakai, C. Meno, H. Fujii, J. Nishino, H. Shiratori, Y. Saijoh, J. Rossant and H. Hamada

Genes Dev (2001) 15:2 213-25. 

Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2.

C. Meno, J. Takeuchi, R. Sakuma, K. Koshiba-Takeuchi, S. Ohishi, Y. Saijoh, J. Miyazaki, P. ten Dijke, T. Ogura and H. Hamada

Dev Cell (2001) 1:1 127-38. 

GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion.

J. Nishino, K. Mochida, Y. Ohfuji, T. Shimazaki, C. Meno, S. Ohishi, Y. Matsuda, H. Fujii, Y. Saijoh and H. Hamada

Neuron (1999) 23:4 725-36. 

Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation.

C. Meno, K. Gritsman, S. Ohishi, Y. Ohfuji, E. Heckscher, K. Mochida, A. Shimono, H. Kondoh, W. S. Talbot, E. J. Robertson, A. F. Schier and H. Hamada

Mol Cell (1999) 4:3 287-98. 

Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry.

H. Yoshioka, C. Meno, K. Koshiba, M. Sugihara, H. Itoh, Y. Ishimaru, T. Inoue, H. Ohuchi, E. V. Semina, J. C. Murray, H. Hamada and S. Noj

Cell (1998) 94:3 299-305. 

lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal.

C. Meno, A. Shimono, Y. Saijoh, K. Yashiro, K. Mochida, S. Ohishi, S. Noji, H. Kondoh and H. Hamada

Cell (1998) 94:3 287-97. 

Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos.

C. Meno, Y. Ito, Y. Saijoh, Y. Matsuda, K. Tashiro, S. Kuhara and H. Hamada

Genes Cells (1997) 2:8 513-24. 

Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor.

Y. Saijoh, H. Fujii, C. Meno, M. Sato, Y. Hirota, S. Nagamatsu, M. Ikeda and H. Hamada

Genes Cells (1996) 1:2 239-52. 

Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos.

C. Meno, Y. Saijoh, H. Fujii, M. Ikeda, T. Yokoyama, M. Yokoyama, Y. Toyoda and H. Hamada

Nature (1996) 381:6578 151-5. 

Synchronous sperm penetration of zona-free mouse eggs in vitro.

Y. Takahashi, C. Meno, E. Sato and Y. Toyoda

Biol Reprod (1995) 53:2 424-30. 

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